Handbook of Grignard Reagents (Chemical Industries)

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An unexpected error occurred. Source: Vy M. This experiment will demonstrate how to properly carry out a Grignard reaction. The formation of an organometallic reagent will be demonstrated by synthesizing a Grignard reagent with magnesium and an alkyl halide. To demonstrate a common use of a Grignard reagent, a nucleophilic attack onto a carbonyl will be performed to generate a secondary alcohol by forming a new C-C bond. Organic Chemistry II.

Synthesis of alcohols using Grignard reagents I - Organic chemistry - Khan Academy

Grignard Reaction. This Nobel-Prize-winning chemistry consists of two steps: Grignard reagent formation and subsequent Grignard addition onto a carbonyl to construct a new carbon-carbon bond. A Grignard reagent is an organometallic compound, specifically an organomagnesium compound. The synthesis of a Grignard reagent requires an alkyl or aryl halide chlorides, bromides, or iodides and magnesium.


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  • Grignard Reactions!

In this step, the electrophilic an electrophile is electron deficient and accepts electrons alkyl halide is transformed into a nucleophilic a nucleophile is electron rich and donates electrons carbanion-like compound. The second step of the Grignard reaction entails a nucleophilic addition of the Grignard reagent onto a carbonyl. After this step, a new carbon-carbon bond is formed and the carbonyl is transformed into an alcohol.

It is important to perform both steps under moisture-free conditions otherwise the Grignard reagent used will react with water, and no desired Grignard or C-C bond formation results. The Grignard reaction is an important and widely used tool that allows synthetic chemists to take any alkyl or aryl halide and transform it into an organomagnesium compound, which can be used to construct carbon-carbon bonds. The Grignard reaction is a useful tool for the formation of carbon-carbon bonds in organic synthesis.


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This reaction was discovered more than a century ago by a French Chemist named Victor Grignard for which he was rewarded a Nobel Prize in The Grignard reaction consists of two steps. The first step is reacting an organohalide with magnesium metal, usually present in the form of turnings. This leads to in situ formation of an organomagnesium halide A. Grignard reagent. The second step is the reaction between this reagent and a carbonyl-containing compound like aldehyde, ketone, or ester, and depending on the compound used, a secondary or tertiary alcohol, composed of organic portions from both the reagent and the carbonyl-containing compound, is produced.

In this video, we will show a step-by-step protocol for preparing allylmagnesium bromide, a frequently used Grignard reagent in chemistry labs.

In-situ production of Grignard reagents in continuous flow - Vapourtec

This will be followed by the procedure for reacting this reagent with trans -cinnamaldehyde to obtain a secondary alcohol. Lastly, we will look at a couple of applications of this reaction. Prior to addition of the reagents, flame-dry a mL flask and stir bar to remove all traces of water, then cool to room temperature under an atmosphere of nitrogen.

This is critical as Grignard reagents are very sensitive to moisture. Next, add oven-dried magnesium turnings and a few crystals of iodine which will facilitate initiation of the reaction by removing any magnesium oxide coating from the metal.


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Subsequently, add 24 mL of anhydrous THF. Place the flask in an ice-water bath to mitigate the heat produced, and with stirring, slowly add allyl bromide via syringe. Then remove the flask from the ice-water bath and allow the reaction mixture to reach room temperature. To ensure completion of the reaction, use gas chromatography to monitor the consumption of allyl bromide.

Once the Grignard reaction is ready for use, prepare for the next step in the reaction. Add to a flame-dried mL flask and stir bar trans-cinnamaldehyde and 30 mL of anhydrous THF, and stir under a nitrogen atmosphere. This is important as in the presence of moisture the Grignard reagent will be destroyed, and will not react with the carbonyl-containing compound. Stir the trans -cinnamaldehyde solution at 0 degrees, and insert a double-tipped needle into the headspace, with the other end inserted into the headspace of the flask containing the Grignard reagent.

Remove the nitrogen-filled balloon from the cinnamaldehyde, and add a nitrogen line to the Grignard flask. Apply positive pressure with the nitrogen line to transfer the Grignard reagent into the cinnamaldehyde.

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After the addition is complete, replace the double-tipped needle with a balloon attachment, remove the cold bath, and stir at room temperature. To determine whether the reaction is complete, use thin layer chromatography to monitor the consumption of trans -cinnamaldehyde. Once it has been determined that the reaction is complete, cool the mixture to 0 degrees, and, while stirring, carefully add 30 mL of saturated aqueous ammonium chloride solution and 50 mL of ethyl acetate.

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In-situ production of Grignard reagents in continuous flow

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